Inhibition of hepatitis B virus replication by interferon requires proteasome activity.
نویسندگان
چکیده
Hepatitis B virus (HBV) replication is inhibited in a noncytopathic manner by alpha/beta interferon (IFN-alpha/beta) and IFN-gamma. We demonstrate here that inhibitors of cellular proteasome activity can block this antiviral effect. These results suggest that a critical component of the IFN-induced antiviral response may be the proteasome-dependent degradation of viral or cellular proteins that are required for HBV replication.
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ورودعنوان ژورنال:
- Journal of virology
دوره 76 7 شماره
صفحات -
تاریخ انتشار 2002